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Realizing Cancer Precision Medicine by Integrating Systems Biology and Nanomaterial Engineering

Jae Il Joo1, Minsoo Choi1, Seong-Hoon Jang1

  • 1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.

Advanced Materials (Deerfield Beach, Fla.)
|April 8, 2020
PubMed

Insights

Systems biology and nanomaterial engineering can overcome cancer drug resistance and low efficacy in precision medicine. This integration enables personalized treatments by addressing complex biomolecular networks and patient heterogeneity.

Area of Science:

  • Biomedical Engineering
  • Computational Biology
  • Oncology

Background:

  • Cancer precision medicine trials face challenges like drug resistance and low efficacy.
  • Drug resistance stems from complex biomolecular regulatory networks within cancer cells.
  • Current systems biology approaches identify targets but face development and clinical application hurdles.

Purpose of the Study:

  • To explore the integration of systems biology and nanomaterial engineering for cancer precision medicine.
  • To address limitations of conventional treatments and nanomedicine in overcoming drug resistance and patient heterogeneity.
  • To enable clinical application of personalized cancer therapies.

Main Methods:

  • Modeling and simulation of complex biomolecular networks using systems biology.
  • Development of nanocarriers for "undruggable" targets and precise drug delivery.
  • Systems biology approaches for identifying personalized targets and enhancing drug responses.

Main Results:

  • Systems biology can unravel drug resistance mechanisms and identify novel therapeutic strategies.
  • Nanocarriers offer solutions for developing therapies against previously untreatable targets.
  • Personalized targeting through systems biology can improve nanomedicine efficacy in heterogeneous cancers.

Conclusions:

  • Integrating systems biology and nanomaterial engineering is crucial for advancing cancer precision medicine.
  • This interdisciplinary approach can overcome major challenges in current cancer therapy.
  • The combined strategy promises more effective and personalized treatments for cancer patients.
Keywords:
cancer precision medicinenanocarriersnanomaterial engineeringnetwork dynamicssystems biology

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