Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

23.5K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
23.5K
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

5.4K
Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
5.4K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

999
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
999
Allosteric Proteins-ATCase01:19

Allosteric Proteins-ATCase

6.4K
Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
6.4K
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

1.0K
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
1.0K
Tail-anchoring of Proteins in the ER Membrane01:45

Tail-anchoring of Proteins in the ER Membrane

3.6K
Tail-anchored, or TA, proteins are estimated to make up to 3-5% of membrane proteins found in the eukaryotic cell. Such proteins have a single transmembrane domain located approximately 30 amino acid residues upstream from the C-terminal end. As a result, the signal recognition particle (SRP) cannot guide a TA protein to the ER membrane for cotranslational insertion. Hence, they are integrated into the ER membrane post-translationally using their C-terminal end as the anchor. TA proteins...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activation of ACE2 by Hazelnut-Derived Peptide YYLLVR: A Novel Strategy against Hypertension-Induced Cognitive Impairment.

Journal of agricultural and food chemistry·2026
Same author

Surgical management of tumor-mimicking posteriorly migrated lumbar disc fragment using a quadrant minimally invasive approach: a case report and literature review.

Frontiers in surgery·2026
Same author

Genesis mechanism of iodide and fluoride in groundwater driven by high-salinity in Bohai Bay.

Journal of contaminant hydrology·2026
Same author

Nitrate pollution sources and associated biogeochemical mechanisms in coastal groundwater affected by seawater intrusion using multiple isotopes and source apportionment models.

Marine pollution bulletin·2026
Same author

A High-Resolution VOC Emission Inventory for Gas Stations in a Typical Yangtze River Delta City: Implications for Ozone Formation, Secondary Organic Aerosol Formation, and Health Risks.

Toxics·2026
Same author

High co-occurrence but low heterogeneity of virulence factors and resistance genes in farmland soil.

Journal of environmental sciences (China)·2026

Related Experiment Video

Updated: Dec 24, 2025

In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions
10:22

In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions

Published on: June 16, 2014

18.7K

Site-specific surface tailoring for metal ion selectivity via under-coordinated structure engineering.

Li Yu1, Gong Zhang, Chunlei Liu

  • 1State Key Laboratory of Environmental Aquatic Chemistry, Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P. R. China. hjliu@rcees.ac.cn.

Nanoscale Horizons
|April 8, 2020
PubMed
Summary

This study introduces a novel method for selective metal ion adsorption by tuning material structure. The developed under-coordinated manganese material effectively targets lead ions, offering a new approach for environmental remediation.

More Related Videos

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

9.7K
Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance
08:12

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance

Published on: September 5, 2018

16.4K

Related Experiment Videos

Last Updated: Dec 24, 2025

In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions
10:22

In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions

Published on: June 16, 2014

18.7K
Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

9.7K
Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance
08:12

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance

Published on: September 5, 2018

16.4K

Area of Science:

  • Materials Science
  • Environmental Chemistry
  • Surface Chemistry

Background:

  • Coordinatively unsaturated atoms are crucial for tuning material properties.
  • Selective adsorption on tailored surface sites remains underexplored.
  • Controlling surface site accessibility is key for targeted applications.

Purpose of the Study:

  • To demonstrate a new concept for selective adsorption by tuning lattice atom chemical states.
  • To develop an under-coordinated manganese structure for preferential lead ion complexation.
  • To create a versatile platform for environmental remediation, resource recovery, and analyte sensing.

Main Methods:

  • Elaborate tuning of lattice atom chemical states.
  • Development of an under-coordinated manganese structure.
  • Assembly of a core-shell structure with exposed edge sites.
  • Investigation of pH-enabled switchable sorption-desorption.

Main Results:

  • The under-coordinated manganese structure preferentially complexes lead (Pb) ions at hydroxylated lateral edge sites.
  • Octahedral vacancy sites, non-specific for metal ions, were reduced.
  • High selectivity coefficients (31.2-172.0) for Pb(II) against other metal cations were achieved.
  • Specificity was maintained even at high coexisting metal cation concentrations.
  • pH-enabled switchable sorption-desorption demonstrated adsorbent recyclability.

Conclusions:

  • Intrinsic structure modification offers a new paradigm for surface site tailoring.
  • The developed strategy enables a versatile and tunable platform for selective adsorption.
  • This approach moves beyond ligand-induced systems for enhanced material functionality.