Responsive crosslinked polymer nanogels for imaging and therapeutics delivery
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Updated: Dec 24, 2025
Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
Published on: January 24, 2025
Antonie E Ekkelenkamp1, M Rachèl Elzes, Johan F J Engbersen
1Department of Biomolecular Nanotechnology, MESA+ Institute for Nanotechnology, Faculty of Science and Technology, University of Twente, P. O. Box 217, 7500 AE, Enschede, The Netherlands. J.M.J.Paulusse@utwente.nl.
Abstract:
Water-soluble, nano-sized crosslinked polymer networks, or nanogels, are delivery vehicles, which have highly interesting properties for therapeutic delivery and imaging. Nanogels may also possess responsive properties, depending on the employed polymers, allowing controlled release of therapeutics or image contrast generation upon exposure to physical or (bio)chemical cues. In this review, polymer nanogels are explored for application in imaging as well as for controlled drug and gene delivery. Moreover, nanogels are explored as responsive biomaterials and future applications are highlighted.
