Related Experiment Video
Updated: Dec 24, 2025

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
Switching off the interactions between graphene oxide and doxorubicin using vitamin C: combining simplicity and
Zhen Liu1, Jingquan Liu, Tao Wang
1Centre for Chemistry and Biotechnology, School of Life and Environmental Sciences, Deakin University, Geelong, VIC 3216, Australia. wenrong.yang@deakin.edu.au.
Abstract:
Well-controlled, low-toxicity and highly efficient delivery systems for anticancer drugs are a key challenge for the development of a new class of nanocarrier systems for cancer chemotherapy. Graphene oxide (GO) has been developed to be a nanocarrier of anti-cancer drugs due to its large surface area and biocompatibility; however, understanding of the interface chemistry is very limited. In this work, we report efficient loading and controlled release of doxorubicin (DOX) using the tunable surface of GO. A deep understanding of the surface chemistry between GO and DOX is achieved using spectroscopies and atomic force microscopy. Hydrogen bonding and π-π stacking are confirmed to be the non-covalent interactions between the drugs and the carriers. As a result, improvement of DOX delivery from the GO surface can be achieved using vitamin C.
More Related Videos
08:57Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
Published on: October 5, 2017
09:09Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
Published on: June 23, 2020
Related Concept Videos
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Drug Delivery: Overview
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Bioavailability Enhancement: Drug Solubility Enhancement
Bioavailability Enhancement: Drug Permeability Enhancement
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention