Related Experiment Video
Updated: Dec 24, 2025
Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
Published on: February 1, 2022
A rapid and highly sensitive strain-effect graphene-based bio-sensor for the detection of stroke and cancer
Duo Lin1, Chinh-Yu Tseng, Qi Feng Lim
1College of Integrated Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.
Abstract:
Here, we propose a highly sensitive and rapid bio-sensor for the detection of bio-markers for stroke and cancer-related diseases, based on the utilization of the adsorption properties of ruthenium carbonyl (Ru-CO) clusters on monolayer graphene (MG). A fast rate of decarbonylation of Ru-CO to form ruthenium oxide nanoparticles (RuO2 NPs) on MG was observed. The quantitative detection of matrix metalloproteinase-2 (MMP-2) (bio-marker for stroke and vascular diseases) was demonstrated by tracking the spectral shift of the characteristic G band of graphene caused by the adsorption of RuO2 NPs. A concentration as low as 17 ng mL-1 of MMP-2 was detected in a simulated clinical serum sample. This effective bio-sensor has the potential to revolutionize the biomedical field in the early detection and possible prevention of stroke and cancer diagnosis.
More Related Videos
09:39Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
Published on: March 31, 2022
09:38Strain Sensing Based on Multiscale Composite Materials Reinforced with Graphene Nanoplatelets
Published on: November 7, 2016