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Mannan-based conjugates as a multimodal imaging platform for lymph nodes.

M Rabyk¹, A Galisova, M Jiratova

¹Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic. mhruby@centrum.cz.

Journal of Materials Chemistry. B

|April 8, 2020

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New mannan conjugates offer advanced multimodal imaging capabilities due to their biocompatibility and self-targeting nature. These novel polymers demonstrate superior performance for lymph node detection compared to existing agents.

Area of Science:

Biomaterials science
Nanotechnology
Medical imaging

Background:

Mannan-based conjugates are promising for biomedical applications.
Multimodal imaging requires agents with biocompatibility and targeting capabilities.

Purpose of the Study:

To develop novel mannan conjugates for enhanced multimodal imaging.
To evaluate their performance in vitro and in vivo for lymph node detection.

Main Methods:

Synthesis of mannan conjugates with gadolinium complexes and fluorescent probes.
Functionalization via alkylation, grafting, thiol-ene click reaction, and N-hydroxysuccinimide ester chemistry.
In vitro and in vivo imaging using magnetic resonance and fluorescence techniques.

Main Results:

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Last Updated: Dec 24, 2025

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Successfully synthesized two distinct mannan conjugates.
Demonstrated simultaneous visualization via magnetic resonance and fluorescence imaging.
Achieved superior lymph node imaging properties compared to a commercial contrast agent.

Conclusions:

Mannan-based conjugates exhibit exceptional features for multimodal imaging.
These novel materials offer improved biocompatibility, biodegradability, and self-targeting properties.
The developed conjugates represent a significant advancement for diagnostic imaging applications.