Related Experiment Video
Updated: Dec 24, 2025
A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
Published on: March 17, 2023
Organic nanoparticles with ultrahigh quantum yield and aggregation-induced emission characteristics for cellular
Jie Liu1, Maximilien Evrard, Xiaolei Cai
1Department of Chemical and biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117585, Singapore. cheliub@nus.edu.sg.
Abstract:
Fluorescent organic nanoparticles based on small molecules have emerged as an attractive class of fluorescent agents for bioimaging in recent years. Herein, we report orange light-emitting BTPEBD based organic nanoparticles (BTPEBD NPs) with a large Stokes shift (>135 nm), ultrahigh quantum yield (>90% in water) and aggregation-induced emission characteristics. Single nanoparticle analysis studied by wide field microscopy imaging further proves that the BTPEBD NPs exhibit high brightness and good photostability. Both in vitro and in vivo experiments reveal that the BTPEBD NPs are promising fluorescent agents for cellular imaging and real-time two-photon lung vasculature imaging.
