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Ca-Doped mesoporous SiO2/dental resin composites with enhanced mechanical properties, bioactivity and antibacterial
Yu Zhang1, Cui Huang, Jiang Chang
1State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China. jchang@mail.sic.ac.cn.
Abstract:
Ca-Doped mesoporous SiO2 (MCS) nanoparticles with diameter of 230 nm were synthesized by a sol-gel method with some modification. As inorganic fillers, they improved the mechanical properties of the resin composites with 5%, 10%, 20% addition (5RC, 10RC, 20RC). After soaking in the simulated oral fluid (SOF), the resin composites showed excellent activity in inducing apatite-mineralization. As mesoporous nanoparticles, they can be used as carriers for loading the antibacterial drug Ciprofloxacin hydrochloride (CiH). The antibacterial testing of the resin composites with MCS-CiH (5RC-CiH, 10RC-CiH, 20RC-CiH) demonstrated excellent antibacterial effects. The incorporation of Ca-doped mesoporous SiO2 into dental resin is a suitable approach for improving the properties of the dental resin, and the MCS/resin composites have the potential for application in preventing secondary-caries.
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