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Updated: Dec 24, 2025
Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies
Published on: May 19, 2022
A 3D printed wound cooling system incorporated with injectable, adsorbable, swellable and broad spectrum
Fanrong Ai1, Tingwu Liu, Yu Liu
1Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330031, China. wangxiaolei@ncu.edu.cn.
Abstract:
Uncontrolled hemorrhage remains a leading cause of early death after trauma, and contamination further challenges the wounded. In the present study, silver nanocluster (or silver nanoparticle) decorated rapidly swellable hemostatic scaffolds (AgNCs/RSHs and AgNPs/RSHs) were prepared. A 3D printed injectable wound cooling hemostatic (IWCH) system was accordingly designed and implemented to realize the relative rapid hemostasis operation. The obtained AgNCs/RSHs and AgNPs/RSHs exhibited excellent biocompatibility and broad-spectrum antibacterial properties including drug resistant strains. In a rabbit femoral vascular injury model, bleeding could be instantly stopped in 10 seconds by using IWCHs. The present study provided a new insight into the development of rapid hemostatic biomaterials to realize a quick, precise and simplified hemostasis operation in less time and with less bleeding.
