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Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
Published on: July 16, 2018
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Nanoparticle-proteome in vitro and in vivo
Miaoyi Wang1, Ove J R Gustafsson, Emily H Pilkington
1ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia. pu-chun.ke@monash.edu thomas.p.davis@monash.edu.
Journal of Materials Chemistry. B
|April 8, 2020
Summary
This review condenses protein corona data from the past decade, crucial for nanomedicine and nanobiotechnology. It analyzes nanoparticle properties, biological context, and methods to understand protein corona formation and in vivo implications.
Area of Science:
- Bio-nano interface science
- Nanomedicine
- Nanobiotechnology
Background:
- The protein corona is a key concept at the bio-nano interface.
- Understanding protein corona formation is essential for advancing nanomedicine and nanobiotechnology.
- A decade of research has generated extensive in vitro and in vivo proteome databases.
Purpose of the Study:
- To review and contextualize protein corona databases accumulated over the last decade.
- To provide a comprehensive resource for researchers in nanomedicine and nanobiotechnology.
- To highlight the implications of protein corona networks in vivo.
Main Methods:
- Analysis of physicochemical characteristics of nanoparticles.
- Evaluation of surface ligands and biological matrices.
- Review of methods used for protein corona analysis.
- Identification of top-ten enriched corona proteins.
Main Results:
- Compilation of in vitro and in vivo protein corona data.
- Identification of key parameters influencing protein corona formation.
- Highlighting of protein coronal networks and their in vivo relevance.
Conclusions:
- The review consolidates a decade of protein corona research.
- Understanding protein corona composition and behavior is critical for safe and effective nanomedicine applications.
- This work serves as a valuable resource for the field.
