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Updated: Dec 24, 2025
Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
Published on: March 22, 2020
Mercaptopyrimidine-directed gold nanoclusters: a suitable fluorescent probe for intracellular glutathione imaging and
Youkun Zheng1, Weiwei Liu, Yun Chen
1State Key Laboratory of Bioelectronics, National Demonstration Center for Experimental Biomedical Engineering Education, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. sungi@seu.edu.cn xuewang@seu.edu.cn.
Abstract:
Herein, we demonstrate a novel, facile, and suitable strategy for imaging GSH based on mercaptopyrimidine-directed gold nanoclusters (Au NCs). GSH can specifically induce the fluorescence enhancement of Au NCs by attacking the surface of the NCs to form dual ligand stabilized Au NCs at the millimolar level. Very importantly, the Au NCs can selectively image cancer cells.
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