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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
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Synthesis of Sr-morin complex and its in vitro response: decrease in osteoclast differentiation while sustaining

Marcos A E Cruz1, Camila B Tovani, Bruno Z Favarin

  • 1Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto - Universidade de São Paulo - Departamento de Química, Brazil. anapr@ffclrp.usp.br.

Journal of Materials Chemistry. B
|April 8, 2020
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Summary
This summary is machine-generated.

A novel strontium-morin complex shows enhanced osteoporosis treatment potential. This strontium complex reduced osteoclast differentiation and improved osteoblast mineralization more effectively than strontium ranelate.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery
  • Nanotechnology

Background:

  • Strontium ranelate (SrR) is a primary osteoporosis treatment, but improved carriers are needed.
  • Developing Sr2+ carriers that also benefit bone metabolism is a key research area.
  • Natural compounds like morin (a flavonoid) are being explored for bone health benefits.

Purpose of the Study:

  • To synthesize and characterize a new strontium (Sr2+) complex using morin as a carrier.
  • To investigate the potential of this Sr-morin complex as an improved osteoporosis therapeutic.
  • To evaluate the complex's efficacy in bone cell differentiation and mineralization.

Main Methods:

  • Synthesis of the Sr-morin complex with formula [(C15H9O7)Sr(H2O)2]Cl·3H2O.
  • Characterization using elemental analysis, thermogravimetry, UV-Vis, FTIR, and 1H-NMR.
  • In vitro studies using preosteoclast cultures and osteoblast mineralization assays.

Main Results:

  • Successful complexation of Sr2+ with morin at the 3-OH and 4C=O groups.
  • The Sr-morin complex significantly reduced osteoclast differentiation.
  • Osteoblast mineralization was sustained, with Sr-morin showing higher efficacy than SrR at equivalent concentrations.

Conclusions:

  • The Sr-morin complex represents a promising alternative for osteoporosis treatment.
  • This complex may offer improved therapeutic effects compared to existing strontium therapies.
  • Potential applications include osteoporosis management and osteointegration materials.