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Gel-like ionic complexes for antimicrobial, hemostatic and adhesive properties.

Jhia-Sin Jhiang1, Tzu-Hsien Wu, Chung-Jung Chou

  • 1R&D Center for Membrane Technology, Chung Yuan Christian University, 200 Chung Pei Rd., Chung-Li City 32023, Taiwan. ychang@cycu.edu.tw.

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|April 8, 2020
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Summary

We created novel gel-like complexes using poly(TMAEMA-co-SBMA) and polyphosphate (PP). These ionic complexes show promise as antimicrobial agents, hemostatic materials, and robust adhesives for diverse applications.

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Area of Science:

  • Polymer Science
  • Materials Science
  • Biomaterials

Background:

  • Ion-specific effects are crucial for designing advanced macromolecular systems.
  • Intelligent polyelectrolyte systems offer tunable properties for various applications.
  • Understanding ion-polymer interactions is key to developing functional materials.

Purpose of the Study:

  • To develop gel-like polyelectrolyte/counterion complexes using ionotropic gelation.
  • To investigate the structure-property relationships of these complexes.
  • To explore their potential in antimicrobial, hemostatic, and adhesive applications.

Main Methods:

  • Ionotropic gelation of poly((trimethylamino)ethyl methacrylate chloride-co-sulfobetaine methacrylate) (poly(TMAEMA-co-SBMA)) with polyphosphate (PP).
  • Varying the molar composition of poly(TMAEMA-co-SBMA) to study effects on complex formation, water content, and viscoelasticity.
  • Utilizing state diagrams to analyze ionic association and complex formation.
  • Evaluating antimicrobial activity, hemostasis in a rat tail-bleeding assay, and adhesive properties on various substrates.

Main Results:

  • Stable, gel-like polyelectrolyte/counterion complexes were successfully formed.
  • The zwitterionic sulfobetaine methacrylate (SBMA) component allowed fine-tuning of complex properties.
  • The complexes demonstrated significant antimicrobial efficacy against pathogenic bacteria.
  • The gels exhibited hemostatic capabilities and functioned as robust, substrate-independent adhesives.

Conclusions:

  • The developed poly(TMAEMA-co-SBMA)/PP complexes exhibit tunable properties based on composition and ionic strength.
  • These ionic complexes show significant potential for biomedical applications, including antimicrobial and hemostatic uses.
  • The material's adhesive properties offer a versatile, water-based alternative to commercial adhesives.