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Updated: Dec 24, 2025

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
Sub-stoichiometric reductive etherification of carbohydrate substrates and one-pot protecting group manipulation
Chiao Wen Chen1, Ching Chi Wang1, Xin Ru Li1
1Applied Chemistry Department, National Chiao Tung University, 1001, University Road, Hsinchu City, Taiwan. tmong@mail.nctu.edu.tw.
Abstract:
In this study, we report a new reductive etherification procedure for protection of carbohydrate substrates and its application for one-pot preparation of glycosyl building blocks. The reported procedure features the use of polymethylhydrosiloxane (PMHS) as a sub-stoichiometric reducing agent, which prevents the transilylation side reaction and improves the efficiency of the reductive etherification method. Application of the PMHS reductive etherification procedure for one-pot protecting group manipulation are described.
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