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Updated: Dec 24, 2025
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Association between the miR-146a Polymorphisms and the Risk of Gastric Cancer: a Meta-Analysis
Background:
Published data regarding associations between the microRNA-146a polymorphism and the risk of gastric cancer are inconclusive. This study aims at evaluating the genetic risk of microRNA-146a polymorphism in gastric cancer.
Methods:
A systematic literature search was carried out in Pubmed, Medline (Ovid), Embase, CBM, CNKI, Weipu, and Wanfang databases, covering all available publications (last search was performed on Apr 15th, 2019). Statistical analysis was performed using Revman 5.2 and STATA 10.1 software.
Results:
A total of 5,017 cases and 4,869 controls in 14 case-control studies were included in this meta-analysis. No significant association between microRNA-146a polymorphism and gastric cancer risk was observed in all kinds of genetic models (homozygote genetic model CC vs. GG: OR = 0.96, 95% CI = 0.81 - 1.15, p = 0.66; the heterozygote genetic model CG vs. GG: OR = 0.94, 95% CI = 0.86 - 1.02, p = 0.15; the recessive genetic model CC vs. CG + GG: OR = 0.98, 95% CI = 0.91 - 1.05; the dominant genetic model CC + CG vs. GG: OR = 0.94, 95% CI = 0.86 - 1.01, p = 0.1, p = 0.55; and the allele genetic model C vs. G: OR = 0.98, 95% CI = 0.89 - 1.06, p = 0.58). In subgroup analysis, the C allele may be a protective factor for gastric cancer development in the analysis of the dominant genetic model (CC + CG vs. GG) in HCC studies (OR = 0.90, 95% CI = 0.83 - 0.98, p = 0.02) but a risk factor in Japanese when calculated with the recessive genetic model (CC vs. CG + GG) (OR = 1.19, 95% CI = 1.02 - 1.40, p = 0.03).
Conclusions:
Based on our meta-analysis, the microRNA-146a polymorphism is unlikely to be a risk factor for gastric cancer in overall population.
Insights
The microRNA-146a polymorphism is not a significant risk factor for gastric cancer overall. However, specific subgroup analyses suggest potential protective or risk roles in certain populations.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Published data on the association between microRNA-146a (MIR146A) gene polymorphism and gastric cancer risk are conflicting.
- Gastric cancer remains a significant global health concern, necessitating further investigation into genetic risk factors.
Purpose of the Study:
- To conduct a comprehensive meta-analysis evaluating the association between microRNA-146a polymorphism and gastric cancer risk.
- To synthesize evidence from existing case-control studies to clarify the role of MIR146A in gastric carcinogenesis.
Main Methods:
- A systematic literature search was performed across multiple databases (PubMed, Medline, Embase, etc.) up to April 15th, 2019.
- Included 14 case-control studies comprising 5,017 gastric cancer cases and 4,869 controls.
- Statistical analyses were conducted using Revman 5.2 and STATA 10.1 software.
Main Results:
- Overall meta-analysis revealed no significant association between microRNA-146a polymorphism and gastric cancer risk across various genetic models.
- Subgroup analysis indicated the MIR146A C allele might be protective in hepatocellular carcinoma (HCC) studies (dominant model) but a risk factor in Japanese populations (recessive model).
Conclusions:
- The microRNA-146a polymorphism is unlikely to be a significant risk factor for gastric cancer in the general population.
- Further research is warranted to explore the nuanced role of MIR146A polymorphism in specific ethnic groups and cancer subtypes.
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