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Immunologic surface markers on nonhuman primate lymphocytes.

T G Terrell, C A Holmberg, B I Osburn

    American Journal of Veterinary Research
    |April 1, 1977
    PubMed
    Summary
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    Rhesus macaque lymphocytes share key T-cell markers with humans. Studies on peripheral blood lymphocytes and thymocytes revealed similar spontaneous rosette formation and surface receptor expression, indicating conserved immune cell characteristics between species.

    Area of Science:

    • Immunology
    • Primate immunology
    • Cellular immunology

    Background:

    • T lymphocytes are crucial immune cells in vertebrates.
    • Human T lymphocytes exhibit specific membrane characteristics, including spontaneous rosette formation with sheep erythrocytes and receptors for complement.
    • Understanding these markers in non-human primates is vital for comparative immunology and preclinical research.

    Purpose of the Study:

    • To investigate and characterize the membrane properties of peripheral blood lymphocytes and thymocytes in rhesus macaques (Macaca mulatta).
    • To compare these lymphocyte markers with those found in human T lymphocytes.
    • To assess the utility of rhesus macaques as models for human immunology studies.

    Main Methods:

    • Analysis of peripheral blood lymphocytes from 37 healthy adult rhesus macaques.

    Related Experiment Videos

  • Examination of thymocytes from 10 fetal and neonatal rhesus macaques.
  • Evaluation of spontaneous rosette formation with sheep erythrocytes.
  • Measurement of membrane-bound immunoglobulin using fluorescent antibody techniques.
  • Assessment of surface receptors for fixed complement via erythrocyte-antibody-complement rosettes.

    • Main Results:

    • Peripheral blood lymphocytes exhibited a mean of 63% +/- 1.0% spontaneous rosettes.
    • Mean percentages for erythrocyte-antibody-complement rosettes were 14.9% +/- 1.2%, and for membrane immunoglobulin-positive cells, 21.9% +/- 2.2%.
    • These lymphocyte marker percentages in rhesus macaques closely resemble those reported for human lymphocytes.

    Conclusions:

    • Rhesus macaques possess lymphocyte populations with membrane characteristics analogous to human T lymphocytes.
    • The findings support the use of rhesus macaques as a relevant model for studying human lymphocyte function and immunology.
    • Conserved immune cell markers suggest shared evolutionary pathways in lymphocyte development and function.