Highly responsive and rapid hydrogen peroxide-triggered degradation of polycaprolactone nanoparticles
Peng-Hao Hsu1, Carina Arboleda2, Alexandra Stubelius3
1Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA. aalmutairi@ucsd.edu.
Abstract:
We synthesized an oxidation-responsive polycaprolactone (O-PCL) bearing pendant arylboronic esters as H2O2-responsive motifs. H2O2 induces fast depolymerization of O-PCL within days. Nanoparticles formulated from O-PCL disintegrate and release payload in response to concentrations of H2O2 (50 μM) that are relevant to human disease.
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