Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vitamins01:30

Vitamins

2.2K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.2K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

7.3K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.3K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

4.7K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
4.7K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

5.6K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
5.6K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

473
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
473
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

357
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
357

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Model Analysis of the American Heart Association's Life's Essential 8: Can Physical Activity Mitigate Cardiovascular Risk Among Low-Income Individuals?

Journal of the American Heart Associationยท2026
Same author

Targeted removal of soluble Fms-like tyrosine kinase 1 in very preterm preeclampsia: a pilot trial.

Nature medicineยท2026
Same author

Butyrophilin 2A2 promotes T cell immunoregulation via CD45 phosphatase activation and protects against murine autoimmune glomerulonephritis and pregnancy loss.

Nature communicationsยท2026
Same author

Pointing Care for Preeclampsia in the Right Direction.

Hypertension (Dallas, Tex. : 1979)ยท2025
Same author

VO 2 Peak: The Emerging End Point For Cardiovascular Outcome Trials in Nephrology.

Kidney360ยท2025
Same author

Serum soluble-fms-like tyrosine kinase 1-to-placental growth factor ratio on Elecsys immunoassay platform predicts preeclampsia with severe features in hospitalized women with hypertensive disorders of pregnancy.

American journal of obstetrics and gynecologyยท2025
Same journal

An image of multiple bullous lesions in a patient on hemodialysis.

Jornal brasileiro de nefrologiaยท2026
Same journal

Position Statement of the Brazilian Society of Nephrology on incremental dialysis.

Jornal brasileiro de nefrologiaยท2026
Same journal

Chronic kidney disease in high-risk populations: the urgent need to close the diagnostic gap through systematic screening.

Jornal brasileiro de nefrologiaยท2026
Same journal

Renal expression of Bach1 and oxidative stress in chronic kidney disease: evidence from a preclinical model.

Jornal brasileiro de nefrologiaยท2026
Same journal

Unraveling the complex web of acute kidney injury: pathways, biomarkers, and future directions.

Jornal brasileiro de nefrologiaยท2026
Same journal

Epidemiology of chronic dialysis treatment among children and adolescents in a capital of Northeastern Brazil.

Jornal brasileiro de nefrologiaยท2026
See all related articles

Related Experiment Video

Updated: Dec 24, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.9K

Vitamin D Toxicity.

Kenneth Lim1, Ravi Thadhani1,2

  • 1Harvard Medical School, Massachusetts General Hospital, Division of Nephrology, Department of Medicine, Boston, MA, EUA.

Jornal Brasileiro De Nefrologia
|April 8, 2020
PubMed
Summary
This summary is machine-generated.

Vitamin D fortification reduced rickets, but widespread supplement use has led to increased vitamin D toxicity globally. This article reviews current data on toxicity, diagnosis, and management.

More Related Videos

Toxicity Study of Zinc Oxide Nanoparticles in Cell Culture and in Drosophila melanogaster
06:47

Toxicity Study of Zinc Oxide Nanoparticles in Cell Culture and in Drosophila melanogaster

Published on: September 19, 2019

11.4K
Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

5.1K

Related Experiment Videos

Last Updated: Dec 24, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.9K
Toxicity Study of Zinc Oxide Nanoparticles in Cell Culture and in Drosophila melanogaster
06:47

Toxicity Study of Zinc Oxide Nanoparticles in Cell Culture and in Drosophila melanogaster

Published on: September 19, 2019

11.4K
Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

5.1K

Area of Science:

  • Nutritional Science
  • Endocrinology
  • Public Health

Background:

  • Vitamin D fortification historically eradicated rickets in the US.
  • Growing awareness of vitamin D's health benefits has increased public interest.
  • Widespread availability of vitamin D supplements is noted globally.

Observation:

  • Unregulated vitamin D formulations are common, lacking guidance for safe use.
  • A significant global increase in vitamin D toxicity cases has been reported.
  • Vitamin D toxicity presents a spectrum from asymptomatic to life-threatening.

Findings:

  • Contemporary data on vitamin D toxicity is crucial for clinical practice.
  • Diagnostic strategies for vitamin D toxicity are evolving.
  • Management approaches for vitamin D toxicity require careful consideration.

Implications:

  • Clinicians must be prepared to manage vitamin D toxicity.
  • Public health strategies may need to address supplement safety and education.
  • Further research is needed on safe vitamin D supplementation levels.