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Taurolidine lock solution for catheter-related bloodstream infections in pediatric patients: A meta-analysis

Yan Sun1, Guanghui Wan1, Liping Liang1

  • 1Zaozhuang Traditional Chinese Medicine Hospital, Zaozhuang, Shandong, P.R. China.

Plos One
|April 8, 2020
PubMed

Insights

Taurolidine lock solutions significantly reduce catheter-related bloodstream infections (CRBSIs) in pediatric patients. Further high-quality trials are needed to confirm these findings for central venous catheter (CVC) use.

Area of Science:

  • Pediatric Infectious Diseases
  • Medical Device Infections
  • Pharmacological Interventions

Background:

  • Catheter-related bloodstream infections (CRBSIs) are a significant cause of morbidity and mortality in pediatric patients with central venous catheters (CVCs).
  • Taurolidine lock solutions are utilized to mitigate CRBSIs in both adult and pediatric populations.

Purpose of the Study:

  • To systematically evaluate the efficacy of taurolidine lock solutions in preventing CRBSIs in pediatric patients through a meta-analysis.
  • To determine the impact of taurolidine on CRBSI incidence and catheter removal rates in children.

Main Methods:

  • A comprehensive literature search was conducted across multiple databases (PubMed, EMBASE, Cochrane Library, etc.) up to November 1, 2019.
  • Included studies were randomized controlled trials (RCTs) comparing taurolidine lock solutions with control for CRBSI prevention in pediatric patients.
  • Meta-analysis was performed on data from four eligible RCTs.

Main Results:

  • Taurolidine significantly reduced the total number of CRBSIs compared to control (RR: 0.23; 95% CI: 0.13, 0.40).
  • A statistically significant reduction in CRBSI incidence (events per 1000 catheter days) was observed with taurolidine (MD: -1.12; 95% CI: -1.54, -0.71).
  • No significant difference was found in the number of catheters removed due to infection between taurolidine and control groups (RR: 0.68; 95% CI: 0.22, 2.10).

Conclusions:

  • Taurolidine lock solutions show potential in significantly reducing CRBSIs in pediatric patients using central venous catheters.
  • The current evidence base is limited by the quality of the included studies.
  • Further large-scale, high-quality randomized controlled trials are necessary to validate these findings.

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