The effect of inspired oxygen concentration on oxidative stress biomarkers in dogs under inhalation anesthesia
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Published on: July 9, 2020
Patarakit Chongphaibulpatana1, Yuu Kumagai1, Daisuke Fukui1
1The United Graduate School of Veterinary Science, Gifu University, Yanagido 1-1, Gifu, Gifu, 501-1193, Japan (Chongphaibulpatana); Laboratory of Veterinary Diagnostic Radiology, The Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Ueda-cho, Morioka, Iwate, 020-8550, Japan (Chongphaibulpatana, Kumagai, Katayama, Uzuka); Laboratory of Small Animal Surgery, The Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Ueda-cho, Morioka, Iwate, 020-8550, Japan (Fukui).
Abstract:
This study investigated oxidative stress biomarkers at 3 different oxygen concentrations in dogs under general anesthesia to determine whether high-concentration oxygen increases oxidative stress. Six healthy beagles were randomly assigned to receive 3 anesthesia protocols (inhalation of 40%, 60%, and 100% oxygen) during 3 hours of general anesthesia with sevoflurane, with at least one week in between each protocol. For each experiment, blood samples were collected at 0, 3, 6, and 24 hours after inhalation of oxygen. Derivatives of reactive oxygen metabolites, biochemical antioxidant potential, superoxide dismutase, and 8-hydroxydeoxyguanosine in the blood did not significantly differ among the 3 groups at any time point. This study is the first comparing high concentrations of oxygen with low concentrations of oxygen for anesthesia in dogs. According to our findings, 100% oxygen may not alter the oxidative stress level in dogs during general anesthesia with sevoflurane for 3 hours.
