Related Experiment Video
Updated: Dec 24, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
User Acceptability and Technical Robustness Evaluation of a Novel Smart Pill Bottle Prototype Designed to Support
Tanja R Zijp1, Daan J Touw1,2,3, Job F M van Boven1,3
1Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
This study found a novel smart pill bottle prototype (SPBP) achieved 88% adherence, demonstrating good usability and technical robustness. This technology shows promise for improving medication adherence management.
Area of Science:
- Biomedical Engineering
- Health Informatics
- Pharmaceutical Sciences
Background:
- Smart medication adherence monitoring devices offer objective drug utilization data.
- These technologies can enhance patient engagement in treatment regimens.
Purpose of the Study:
- To assess the acceptability and technical robustness of a novel smart pill bottle prototype (SPBP).
- To gather data for further optimization of the SPBP for clinical and research applications.
Main Methods:
- A proof-of-concept study involving ten volunteers using the app-controlled SPBP for 2 weeks.
- Data collected included dispense adherence, system usability (SUS), self-reported adherence (MARS), and sensor accuracy (temperature).
Main Results:
- The SPBP achieved an overall dispense adherence rate of 88%.
- Participants reported high system usability (mean SUS score 79.3) and good self-reported adherence (MARS 23.6/25).
- The bottle's temperature sensors demonstrated accuracy within -0.82°C of calibrated sensors.
Conclusions:
- The smart pill bottle prototype (SPBP) was well-accepted by users.
- Findings support further development and indicate potential for smart adherence technologies to transform medication management.
Related Concept Videos
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Biopharmaceutical Factors Influencing Drug Product Design: Overview

