Related Experiment Video
Updated: Dec 24, 2025
09:50
Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
Published on: February 12, 2015
11.5K
Acute Effects of 2C-E in Humans: An Observational Study
Esther Papaseit1,2, Eulalia Olesti3,4, Clara Pérez-Mañá1,2
1Clinical Pharmacology Unit, Hospital Universitari Germans Trias i Pujol-Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), Badalona, Spain.
Frontiers in Pharmacology
|April 8, 2020
Summary
2,5-Dimethoxy-4-ethylphenethylamine (2C-E), a novel psychoactive substance, causes psychedelic effects by interacting with serotonin receptors. This study assessed its acute physiological and subjective effects in humans, finding dose-dependent alterations in perception and mood.
Area of Science:
- Pharmacology
- Neuroscience
- Psychiatry
Background:
- 2,5-Dimethoxy-4-ethylphenethylamine (2C-E) is a psychoactive phenethylamine with a structure similar to mescaline.
- It functions as a novel psychoactive substance (NPS) and a partial agonist of serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors.
- Limited research exists on the human pharmacology and pharmacokinetics of 2C-E.
Purpose of the Study:
- To investigate the acute physiological and subjective effects of 2C-E in humans.
- To evaluate the pharmacokinetics of 2C-E following oral administration.
- To characterize the psychoactive properties of 2C-E in recreational users.
Main Methods:
- An observational study involving ten recreational psychedelic users self-administering single oral doses of 2C-E (6.5-25 mg).
- Monitoring of physiological parameters (blood pressure, heart rate) and subjective effects using validated scales (VAS, ARCI, VESSPA-SSE) over 6 hours.
- Saliva samples collected for 6 hours to determine 2C-E concentrations and pharmacokinetic profile.
Main Results:
- 2C-E administration resulted in psychedelic effects, including altered perceptions, hallucinations, and euphoria.
- Maximal 2C-E concentrations in saliva were observed approximately 2 hours post-administration.
- Physiological effects and subjective experiences were dose-dependent.
Conclusions:
- Oral 2C-E at recreational doses produces psychedelic-like effects, comparable to 2C-B and other serotonin-acting agents.
- The study provides initial human data on the acute effects and pharmacokinetics of 2C-E.
- Further research is warranted to fully understand the safety and long-term implications of 2C-E use.
