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Published on: July 11, 2015
Diagnostic Value of Interferon-Gamma Release Assays Combined with Multiple Indicators for Tuberculous Peritonitis
Xidong He1, Yuanxue Gao1, Qi Liu1
1Department of Gastroenterology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
Objective:
To investigate the diagnostic value of interferon-gamma release assays combined with multiple indicators for tuberculous peritonitis.
Methods:
Patients who were admitted to the hospital due to suspected tuberculous peritonitis were prospectively included during the 30-month study period. Moreover, healthy individuals were recruited and included in the control group. All the study participants were assessed using various indexes, such as interferon-gamma release assays.
Results:
A total of 180 patients with suspected tuberculous peritonitis were enrolled, and 24 were excluded. 73 patients with a confirmed diagnosis of tuberculous peritonitis were included in the tuberculous peritonitis group, 83 patients with other diseases in the other-disease control group, and 52 healthy individuals in the control group. Moreover, 83 patients in the other-disease control group and 52 participants in the control group were identified as 135 nontuberculous peritonitis patients. The area under the receiver operating characteristics curve for the QuantiFERON-TB test was 0.851 (95% confidence interval: 0.799-0.903), and the optimal cutoff value was 0.55 IU/mL, which corresponds to a sensitivity and specificity of 86.30% and 80.00%, respectively. The receiver operating characteristic curves for the combination of the QuantiFERON-TB test and the use of erythrocyte sedimentation rate, serum adenosine deaminase level, serum cancer antigen 125 level, and hypersensitive C-reactive protein level had an area under the curve of 0.859 (95% confidence interval: 0.809-0.909), with a sensitivity and specificity of 97.26% and 62.96%, respectively.
Conclusions:
The combined use of the QuantiFERON-TB test and multiple indexes can significantly improve the accuracy of diagnosing tuberculous peritonitis.
Insights
Combining interferon-gamma release assays with other indicators improves the diagnosis of tuberculous peritonitis. This approach enhances accuracy for identifying this serious condition.
Area of Science:
- Infectious Diseases
- Diagnostic Medicine
- Immunology
Background:
- Tuberculous peritonitis is a significant diagnostic challenge.
- Accurate and timely diagnosis is crucial for effective treatment.
Purpose of the Study:
- To evaluate the diagnostic utility of interferon-gamma release assays (IGRAs) for tuberculous peritonitis.
- To assess the added value of combining IGRAs with other clinical and biochemical markers.
Main Methods:
- Prospective study including patients with suspected tuberculous peritonitis and healthy controls.
- Assessment using QuantiFERON-TB Gold test alongside erythrocyte sedimentation rate, serum adenosine deaminase, cancer antigen 125, and C-reactive protein levels.
Main Results:
- The QuantiFERON-TB Gold test alone showed good diagnostic performance (AUC 0.851).
- Combining the QuantiFERON-TB Gold test with erythrocyte sedimentation rate, serum adenosine deaminase, cancer antigen 125, and C-reactive protein significantly improved diagnostic accuracy (AUC 0.859).
Conclusions:
- The combination of QuantiFERON-TB Gold test and multiple biomarkers offers enhanced diagnostic accuracy for tuberculous peritonitis.
- This integrated approach aids in differentiating tuberculous peritonitis from other conditions.
