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Updated: Dec 24, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Effects of Developmental Care on Neurodevelopment of Preterm Infants
Farin Soleimani1, Nadia Azari1, Hesam Ghiasvand2,3
11.Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Insights
This systematic review examines how developmental care impacts neurodevelopment in preterm infants within the neonatal intensive care unit (NICU). Findings will inform best practices for improving infant outcomes.
Area of Science:
- Neonatal Medicine
- Developmental Psychology
- Evidence-Based Practice
Background:
- Preterm infants in the neonatal intensive care unit (NICU) face significant neurodevelopmental challenges.
- Developmental care strategies aim to minimize stress and promote optimal development in vulnerable neonates.
- A systematic review is needed to synthesize current evidence on the efficacy of developmental care.
Purpose of the Study:
- To systematically review and examine the effects of developmental care on the neurodevelopment of preterm infants in the NICU.
- To evaluate the impact of developmental care on mental and motor development, as well as neonatal weight gain and length of NICU stay.
Main Methods:
- Comprehensive literature search across multiple databases (Web of Science, PubMed, EMBASE, CENTRAL, CINAHL, Scopus).
- Inclusion of randomized controlled trials, with data extraction and risk of bias assessment by two independent reviewers.
- Meta-analysis using Review Manager 5.3 and STATA 14 to quantify the effects of developmental care interventions.
Main Results:
- (Study protocol; results pending completion of systematic review and meta-analysis)
- (Specific findings on neurodevelopmental outcomes, weight gain, and length of stay will be reported upon study completion)
- (Assessment of publication bias using Egger's test and funnel plots)
Conclusions:
- (Conclusions will be drawn based on the synthesized evidence from the meta-analysis)
- (Implications for clinical practice and future research directions will be discussed)
- (Evidence-based recommendations for optimizing developmental care in the NICU will be provided)
Objectives:
The aim of this study protocol is to systematically review the literature to examine the effects of developmental care on preterm infants' neurodevelopment in the neonatal intensive care unit (NICU).
Materials & Methods:
Studies will be retrieved through searching the following databases: Web of Science, PubMed, EMBASE (Ovid), Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL (EBSCO), and Scopus. Randomized controlled trials will be included with randomization at either individual or cluster level. The primary outcome will be to evaluate the effect of developmental care on the mental and motor development of NICU neonates. The secondary outcome will be neonatal weight gain and length of stay during NICU hospitalization. The assessment tool for the development should be the Bayley Scales of Infant and Toddler Development, in any of the first, second and third editions. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) will be employed to identify relevant articles and report the screening process. The agreement between two experts in developmental neonatology will be reached in selecting all studies. Afterward, data will be extracted and compared by two reviewers. Any discrepancies in the extracted data will be discussed to reach a consensus. The extracted data will be imported to Review Manager 5.3 by one reviewer. Finally, the risk of bias for all selected studies will be independently evaluated by two reviewers using the Cochrane Collaboration's tool. A meta-analysis will be performed to assess the possible quantitative impact of developmental interventions on the desired primary and secondary objectives. A random effect will be used if the I-square statistics is equal or more than 75%; otherwise, a fixed effect will be applied. Publication bias will be assessed using Egger's test and illustration with the funnel plot. The Standardized Mean Difference (SMD) with 95% confidence interval will be estimated through Metan command in STATA 14. The method provided in the Cochrane handbook will be used in this statistical analysis. The significance level will be 0.05.
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