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Slowly developing toxic epidermal necrolysis-like reaction associated with pemetrexed and carboplatin
1Capital and Coast District Health Board, Dermatology Service, Wellington Hospital, Wellington, New Zealand.
Abstract:
Most cutaneous adverse drug reactions reported in association with chemotherapy, such as a limited maculopapular rash, are considered mild and do not affect the continuation of the treatment. Toxic epidermal necrolysis (TEN), however, is a life-threatening reaction that needs treatment discontinuation. The present case shows the slow progression from a pemetrexed and carboplatin-associated maculopapular rash to a TEN-like reaction.
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