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Related Experiment Videos

Endocrine cell hyperplasia and appendiceal carcinoids.

S S Cross1, A D Hughes, G T Williams

  • 1Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff, U.K.

The Journal of Pathology
|December 1, 1988
PubMed
Summary

Appendiceal carcinoid tumors are linked to increased enterochromaffin (EC) cells in the crypts. This suggests that EC cell hyperplasia may predispose individuals to developing these rare endocrine tumors.

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Area of Science:

  • Gastroenterology
  • Endocrinology
  • Surgical Pathology

Background:

  • Endocrine tumors can develop in hyperplastic tissue.
  • Appendiceal carcinoid tumors are a type of endocrine tumor.

Purpose of the Study:

  • To compare endocrine cell density in appendiceal carcinoid tumor patients versus controls.
  • To investigate the relationship between endocrine cell hyperplasia and appendiceal carcinoid tumor development.

Main Methods:

  • Quantified endocrine cells in crypts and lamina propria.
  • Compared cell densities between 10 carcinoid tumor patients and 10 matched controls.

Main Results:

  • Significantly higher density of argentaffin endocrine cells in appendiceal crypts of carcinoid tumor patients.

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  • No significant difference in non-argentaffin cells or lamina propria cells between groups.

    • Conclusions:

    • Appendiceal carcinoid tumors are associated with increased crypt endocrine cells.
    • EC cell hyperplasia is likely a precursor to appendiceal carcinoid tumors.