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An evidence-based framework for priority clinical research questions for COVID-19
Carlyn Harris1,2, Gail Carson3,4, J Kenneth Baillie4,5
1Emory University School of Medicine, Atlanta, Georgia, USA.
Journal of Global Health
|April 8, 2020
Summary
This study outlines priority clinical research for COVID-19, the novel coronavirus, by reviewing severe coronavirus outbreaks. It identifies research gaps and recommends standardized protocols for real-time clinical practice.
Area of Science:
- Infectious Diseases
- Clinical Research
- Public Health
Background:
- The 2019 novel coronavirus (COVID-19) outbreak has led to over 75,000 global cases and 2,000 deaths.
- Novel agent outbreaks offer opportunities for clinical research to guide public health responses.
- Previous systematic reviews identified research priorities for SARS-CoV and MERS-CoV.
Purpose of the Study:
- To review available information on COVID-19.
- To provide an evidence-based framework for priority clinical research in the current COVID-19 outbreak.
- To compare COVID-19 research with findings from SARS-CoV and MERS-CoV.
Main Methods:
- Systematic review of clinical studies on SARS-CoV and MERS-CoV.
- Thematic grouping of studies based on clinical research questions.
- Review and comparison of February 2020 COVID-19 information with previous systematic review findings.
Main Results:
- Ten research themes were identified for SARS-CoV and MERS-CoV: clinical characterization, prognosis, diagnosis, management, pathogenesis, epidemiology, infection control, susceptibility, psychosocial aspects, and etiology.
- For COVID-19, information is available on clinical presentation, diagnostics, and etiology.
- Significant clinical research gaps remain for COVID-19.
Conclusions:
- A summary of clinical research status for COVID-19 based on severe coronavirus outbreaks.
- Highlighting critical research gaps in COVID-19 clinical studies.
- Recommending standardized protocols to inform clinical practice in real-time.
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