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Relationship between miR-155 and miR-146a polymorphisms and susceptibility to multiple sclerosis in an Egyptian

Marwa Ahmed Ali1, Olfat Gamil Shaker2, Hanaa Mohamed Eid3

  • 1Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum 63514, Egypt.

Biomedical Reports
|April 8, 2020
PubMed

Insights

Genetic variations in miR-155 and miR-146a influence multiple sclerosis (MS) risk. The miR-155 T allele increases MS susceptibility, while the miR-146a G allele offers protection in Egyptian patients.

Area of Science:

  • Neuroimmunology
  • Genetics
  • Autoimmune Diseases

Background:

  • Multiple sclerosis (MS) is a central nervous system autoimmune disorder.
  • MicroRNAs (miRNAs), specifically miR-155 and miR-146a, play roles in MS.
  • Single nucleotide polymorphisms (SNPs) in these miRNAs are linked to autoimmune disease susceptibility.

Purpose of the Study:

  • To investigate the association between two specific miRNA polymorphisms (miR-155 rs767649 A>T and miR-146a rs57095329 A>G) and MS susceptibility in an Egyptian cohort.
  • To determine if these polymorphisms correlate with disease severity or subtype.

Main Methods:

  • Quantitative PCR was used to analyze the presence of miR-155 rs767649 A>T and miR-146a rs57095329 A>G polymorphisms.
  • The study included 114 Egyptian patients with MS and 152 healthy controls.

Main Results:

  • The TT genotype and T allele of miR-155 (rs767649 A>T) were associated with an increased risk of MS.
  • The G allele of miR-146a (rs57095329 A>G) showed a protective effect against MS development.
  • miR-155 rs767649 polymorphism was a risk factor in females but not males.
  • Specific genotypes of both polymorphisms were more prevalent in patients with higher Expanded Disability Status Scale scores and secondary progressive MS.

Conclusions:

  • The miR-155 rs767649 polymorphism may confer susceptibility to MS in the Egyptian population.
  • The miR-146a rs57095329 polymorphism might offer protection against MS.
  • These findings highlight the role of specific miRNA genetic variations in MS pathogenesis and progression.
Keywords:
miR-146a rs57095329miR-155 rs767649multiple sclerosispolymorphismquantitative PCR

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