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Role of rat sarcoma virus mutations in cancer and potential target for cancer therapy

Sanjana S Murdande1

  • 1ROSS University School of Medicine, Lloyd Erskine Sandiford Center, St Michael BB11039, Barbados.

Future Science OA
|April 8, 2020
PubMed

Insights

Oncogenic rat sarcoma virus (RAS) mutations are key drivers in cancer. Understanding RAS mutations and their complex signaling pathways is crucial for developing effective targeted cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Oncogenic rat sarcoma virus (RAS) mutations are prevalent in many cancers.
  • RAS mutations significantly impact cancer molecular biology and signaling pathways.
  • Targeting RAS and its downstream effectors represents a promising strategy in cancer therapy.

Purpose of the Study:

  • To review the role of RAS mutations in cancer development.
  • To discuss the potential of RAS and its effectors as therapeutic targets.
  • To highlight the challenges in developing targeted RAS-based therapies.

Main Methods:

  • Literature review of studies on RAS mutations in cancer.
  • Analysis of RAS signaling pathways and their therapeutic implications.
  • Evaluation of novel therapeutic agents targeting RAS.

Main Results:

  • RAS mutations are central to cancer pathogenesis.
  • Targeting RAS, Grb2, MAPK, and using agents like farnesyltransferase show therapeutic promise.
  • Cancer cells exhibit complex adaptive feedback mechanisms in response to RAS-targeted therapies.

Conclusions:

  • Targeted therapies require a deep understanding of specific cancer dependencies on RAS mutations.
  • Further research into RAS signaling complexity is essential for advancing cancer treatment.
  • RAS mutations remain a critical focus for developing next-generation cancer therapies.
Keywords:
RASRAS-mitogenanticancercancergenegene therapymutationoncogenepersonalized medicinetarget

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