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Related Experiment Video

Updated: Dec 24, 2025

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
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Rare Systemic Response to Titanium Spinal Fusion Implant: Case Report.

Wendy S Towers1, Khalid Kurtom2

  • 1Neurosurgery, University of Maryland Shore Regional Health, Easton, USA.

Cureus
|April 8, 2020
PubMed
Summary
This summary is machine-generated.

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Articles linked to this work by shared authors, journal, and citation graph.

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Intraneural Hemangioma: A Report of Two Cases.

Cureus·2026
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Minimally Invasive Resection of a Thoracic Intradural Extramedullary Cyst: 2-Dimensional Operative Video.

Operative neurosurgery (Hagerstown, Md.)·2022
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Minimizing cortical disturbance to access ventricular subependymoma - A novel approach utilizing spinal minimally invasive tubular retractor system.

Surgical neurology international·2019
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Modified Minimally Invasive Transforaminal Lumbar Interbody Fusion Technique Can Potentially Improve Safety of Interbody Graft Placement.

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Stand-alone LLIF Lateral Cage Migration: A Case Report.

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Delayed upper extremity paresthesia post permanent implantation of five lead spinal cord stimulator for low back and lower extremity pain: A case report.

Clinical neurology and neurosurgery·2015

Systemic titanium hypersensitivity is a rare complication of spinal implants. Removing the hardware can rapidly improve patient well-being and resolve symptoms like fatigue and anorexia.

Area of Science:

  • Neurosurgery
  • Allergy and Immunology
  • Orthopedic Surgery

Background:

  • Titanium spinal implants are common in neurosurgery.
  • Hypersensitivity reactions to titanium implants are rare and difficult to diagnose.
  • Symptoms can be mistaken for infection or depression.

Observation:

  • A 67-year-old female with a history of nickel allergy developed anorexia and fatigue post-thoracic spinal fixation.
  • Symptoms persisted for two years, leading to significant weight loss.
  • Local reactions were not the primary concern.

Findings:

  • The patient experienced a systemic titanium hypersensitivity reaction.
  • Removal of the titanium spinal hardware resulted in rapid weight gain and improved well-being.
Keywords:
auto-immune inflammatory syndromemetal allergyspinal implantstitanium hypersensitivity

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  • This suggests a systemic reaction rather than a localized issue.

    • Implications:

    • Spine surgeons should consider systemic titanium hypersensitivity in patients with unexplained post-operative symptoms.
    • Early identification and hardware removal may prevent long-term morbidity.
    • Further research is needed to understand the mechanisms of titanium hypersensitivity.