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Updated: Dec 24, 2025

Preparation of Biopolymer Aerogels Using Green Solvents
Published on: July 4, 2016
Investigation of Parameters that Affect Resin Swelling in Green Solvents
Chidi Amadi-Kamalu1, Holly Clarke1, Matthew McRobie1
1Department of Chemistry University of York York UK YO10 5DD.
Abstract:
The influence of various physical and chemical factors on the swelling of polystyrene and PEG based resins in greener organic solvents has been systematically investigated. In general, chemical factors: the nature of the functionality/linker and the degree of loading were found to have a far larger influence on the swelling of the resins than physical parameters such as bead size. The results are interpreted in terms of Hansen solubility parameters for the solvents and there is evidence that some solvents interact with the polymeric core of a resin whilst others interact with the functionality. The results are extended to a study of the changes in resin swelling observed during both deprotection and chain elongation reactions during solid phase peptide synthesis.
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