Primary advanced pulmonary synovial sarcoma treated with a multidisciplinary approach

Area of Science:

• Oncology
• Thoracic Surgery
• Medical Research

Background:

• Pulmonary synovial sarcoma (SS) is a rare malignancy.
• Advanced stages often present with poor prognoses.

Observation:

• A 61-year-old woman presented with a large (13-cm) right lower lobe tumor.
• Diagnosis confirmed as advanced pulmonary SS with pleural metastasis via immunohistochemistry.
• Recurrence with brain metastases was observed.

Findings:

• Pneumonectomy was performed for diagnosis and treatment.
• A multimodal treatment sequence included radiosurgery, doxorubicin, eribulin, and pazopanib.
• The patient achieved a survival of 29 months.

Implications:

• Multimodal therapy may improve survival outcomes for advanced pulmonary SS.
• This case highlights the potential benefit of combining treatment modalities.
• Further research into optimal treatment strategies for advanced SS is warranted.