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Glycoconjugation: An approach to cancer therapeutics

Maria I Molejon1, Gisela Weiz1, Javier D Breccia1

  • 1Institute of Earth and Environmental Sciences from La Pampa (INCITAP), National University of La Pampa, School of Natural Sciences (CONICET-UNLPam), Santa Rosa 6300, La Pampa, Argentina.

World Journal of Clinical Oncology
|April 8, 2020
PubMed

Insights

Glycosylation enhances antitumor drugs for gastrointestinal tumors, improving drug delivery and reducing side effects. This review explores how glycosylated drugs target tumors, offering new therapeutic options.

Area of Science:

  • Oncology
  • Pharmacology
  • Drug Delivery

Background:

  • Cancer is a leading global cause of death, with limited treatment options for advanced gastrointestinal tumors.
  • Current therapies for gastrointestinal tumors are effective only for a small patient subset at diagnosis.
  • Novel therapeutic strategies are crucial for managing advanced-stage gastrointestinal cancers.

Purpose of the Study:

  • To review the impact of glycosylation on antitumor agents for gastrointestinal tumors.
  • To examine the tumor-targeting capabilities of glycosylated drugs.
  • To assess the potential of glycosylated antitumor agents in improving treatment outcomes.

Main Methods:

  • Literature review of studies on glycosylated antitumor agents.
  • Analysis of pharmacokinetic and pharmacodynamic properties of glycodrugs.
  • Evaluation of targeting efficiency in gastrointestinal tumor models.

Main Results:

  • Glycosylation improves drug pharmacokinetic profiles, including half-life and reduced side effects.
  • Glycosylated antitumor agents demonstrate enhanced targeting of gastrointestinal tumor tissues.
  • Reduced drug dosages are feasible with glycosylated agents due to improved targeting.

Conclusions:

  • Glycosylation is a promising strategy for developing effective antitumor agents against gastrointestinal tumors.
  • Targeted delivery of glycosylated drugs offers a potential advantage in cancer therapy.
  • Further research into glycosylated antitumor agents could lead to improved patient outcomes.
Keywords:
Antitumoral agentsDrug targetingGastrointestinal cancersGlycosylationTherapeutic strategies

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