Search for abnormal proteins in erythrocytes and plasma from patients with a major depressive episode

A sensitive double-label two dimensional gel electrophoresis procedure has been used to search for abnormal proteins in plasma and erythrocyte plasma membranes from patients with major depressive illness. For both plasma and erythrocytes, minor qualitative and quantitative differences between the proteins in pooled samples from depressed and normal subjects were observed; however, these were shown to be artifacts and no consistent differences were found.