Hepatic alterations associated with fine particulate matter exposure

Several studies have pointed to fine particulate matter (PM_2.5) as the main responsible for air pollution toxic effects. Indeed, PM_2.5 may not only cause respiratory and cardiovascular abnormalities but it may also affect other organs such as the liver. Be that as it may, only a few studies have evaluated the PM_2.5 effects on hepatic tissue. Moreover, most of them have not analyzed the relationship between particles composition and toxicological effects. In this study, healthy rats were subjected to urban levels of PM_2.5 particles in order to assess their structural and functional effects on the liver. During the exposure periods, mean PM_2.5 concentrations were slightly higher than the value suggested by the daily guideline of the World Health Organization. The exposed rats showed a hepatic increase of Cr, Zn, Fe, Ba, Tl and Pb levels. This group also showed leukocyte infiltration, sinusoidal dilation, hydropic inclusions and alterations in carbohydrates distribution. These histologic lesions were accompanied by serological changes, such as increase of total cholesterol and triglycerides, as well as genotoxic damage in their nuclei. We also observed significant associations between several biomarkers and PM_2.5 composition. Our results show that exposure to low levels of PM_2.5 might cause histologic and serological changes in liver tissue, suggesting that PM_2.5 toxicity is influenced not only by their concentration but also by their composition and the exposure frequency.