Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multisystem neuronal degeneration in cocker spaniels.

A Jaggy1, M Vandevelde

  • 1Institute of Animal Neurology, University of Berne, Switzerland.

Journal of Veterinary Internal Medicine
|July 1, 1988
PubMed
Summary

A newly identified hereditary canine disease causes progressive neurologic decline in young Cocker Spaniels. This multisystem neuronal degeneration involves brain lesions and requires postmortem examination for definitive diagnosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differences in Epidural Pathology between Cervical and Thoracolumbar Intervertebral Disk Extrusions in Dogs.

Journal of veterinary internal medicine·2017
Same author

Endothelin-1 Immunoreactivity and its Association with Intramedullary Hemorrhage and Myelomalacia in Naturally Occurring Disk Extrusion in Dogs.

Journal of veterinary internal medicine·2016
Same author

Neurohistological abnormalities during early porcine endotoxemia.

Acta anaesthesiologica Scandinavica·2015
Same author

Targeted surveillance for bovine spongiform encephalopathy.

The Veterinary record·2015
Same author

Multifocal ischemic brain infarctions secondary to spontaneous basilar artery occlusion in a dog with systemic thromboembolic disease.

Journal of veterinary internal medicine·2014
Same author

The fetal patient -- ethical aspects of fetal therapy.

Facts, views & vision in ObGyn·2014

Area of Science:

  • Veterinary Neurology
  • Canine Genetics
  • Neurobiology

Background:

  • Progressive neurologic signs like ataxia and mental deterioration were observed in young Cocker Spaniels.
  • Pathological findings included diffuse nerve cell loss, gliosis, axonal degeneration, and demyelination in the brain.

Purpose of the Study:

  • To characterize a novel, likely hereditary, neurological disorder in young Cocker Spaniels.
  • To differentiate this condition from known canine neurological diseases.

Main Methods:

  • Clinical observation of affected dogs.
  • Postmortem pathological examination of brain tissue.
  • Pedigree analysis to assess hereditary patterns.

Main Results:

  • Identified a unique multisystem neuronal degeneration in four Cocker Spaniels.
  • Confirmed hereditary etiology through pedigree analysis.
  • Lesions consistent with widespread neuronal damage across brain regions.

Conclusions:

  • This study describes a previously unreported hereditary canine neurological disease.
  • The condition presents similarities to human degenerative neurological disorders.
  • Differential diagnoses include cerebellar degeneration and lysosomal storage diseases, with postmortem examination being definitive.

Related Experiment Videos