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High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease 2019

Wei Cao1, Xiaosheng Liu2, Tao Bai3

  • 1Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Open Forum Infectious Diseases
|April 8, 2020
PubMed

Insights

Severe COVID-19 patients showed satisfactory recovery after receiving high-dose intravenous immunoglobulin (IVIg). Further randomized studies of IVIg are recommended for deteriorating coronavirus disease 2019 patients.

Area of Science:

  • Infectious Diseases
  • Immunology

Background:

  • The rapid global spread of coronavirus disease 2019 (COVID-19) presents a significant public health challenge.
  • Effective treatments for severe COVID-19 remain limited, necessitating exploration of novel therapeutic strategies.

Purpose of the Study:

  • To evaluate the potential efficacy of high-dose intravenous immunoglobulin (IVIg) in patients with severe COVID-19.
  • To report on clinical observations of COVID-19 patients treated with IVIg.

Main Methods:

  • Case series reporting on three patients with severe COVID-19.
  • Administration of high-dose intravenous immunoglobulin (IVIg) as a therapeutic intervention.

Main Results:

  • All three patients with severe COVID-19 experienced satisfactory recovery following high-dose IVIg treatment.
  • Clinical improvement was observed in the treated patient cohort.

Conclusions:

  • High-dose intravenous immunoglobulin (IVIg) may be a promising treatment option for severe COVID-19.
  • Randomized controlled trials are warranted to confirm the efficacy of IVIg in deteriorating COVID-19 patients.

Keywords:
coronavirus disease 2019high-dose intravenous immunoglobulinimmunomodulation

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