Related Experiment Video

Updated: Dec 24, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

6.8K

Sodium intake and infection in the early stages of life

Catarina Monteiro1, Ana Rute Costa1, Bárbara Peleteiro1,2

  • 1EPIUnit - Institute of Public Health, University of Porto, Porto, Portugal.

Porto Biomedical Journal
|April 8, 2020
PubMed

Insights

This study found no link between early-life sodium intake and Helicobacter pylori (H. pylori) infection in children. Researchers investigated sodium exposure and H. pylori in 503 children up to age four.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Nutritional Epidemiology

Background:

  • Helicobacter pylori infection, acquired in childhood, elevates gastric cancer risk.
  • High sodium intake may promote pre-malignant gastric lesions and potentiate H. pylori effects.
  • Understanding the interplay between diet and infection in early life is crucial for long-term health.

Purpose of the Study:

  • To assess sodium exposure in children up to 4 years of age.
  • To determine the association between sodium intake and H. pylori infection in this cohort.
  • To provide novel insights into early-life dietary influences on H. pylori.

Main Methods:

  • Prospective cohort study (Generation XXI) with 503 children.
  • Data collected on socio-demographics, diet (at 6 months and 4 years), and H. pylori status (serum ELISA at 4 years).
  • Sodium intake scores calculated; logistic regression used to analyze associations.

Main Results:

  • H. pylori infection detected in 28.2% of children by age 4.
  • 26% of children had sodium intake exceeding WHO recommendations.
  • No significant association found between overall sodium intake and H. pylori infection, with one minor exception at 6 months.

Conclusions:

  • No evidence of an association between sodium intake and H. pylori infection in children up to 4 years.
  • This is the first study to investigate the influence of sodium intake on H. pylori infection in early childhood.
  • Further research may be needed to explore potential long-term effects or different exposure windows.
Abstract

Keywords:
ChildrenCohortDietHelicobacter pyloriSodium

More Related Videos

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

2.5K
Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat08:27

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat

Published on: October 29, 2014

11.5K

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.1K
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.5K
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
673
Stages of Infection01:26

Stages of Infection

Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.5K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
409
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
215