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Diseases of the Liver and Gallbladder

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...

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Related Experiment Video

Updated: Dec 24, 2025

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

Bile Acid Diarrhea and NAFLD: Shared Pathways for Distinct Phenotypes.

Michael J Weaver¹, Scott A McHenry¹, Gregory S Sayuk^1,2

¹Division of Gastroenterology Washington University School of Medicine St. Louis MO.

Hepatology Communications

|April 8, 2020

Summary

Altered bile acid (BA) signaling impacts both Irritable Bowel Syndrome with Diarrhea (IBS-D) and Non-Alcoholic Fatty Liver Disease (NAFLD). Understanding these shared pathways, particularly involving fibroblast growth factor 19 (FGF19), may lead to new targeted therapies.

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Last Updated: Dec 24, 2025

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Published on: November 27, 2016

Inducing and Characterizing Vesicular Steatosis in Differentiated HepaRG Cells

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DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

Area of Science:

Gastroenterology
Hepatology
Metabolic Disorders

Background:

Irritable bowel syndrome with diarrhea (IBS-D) and Non-Alcoholic Fatty Liver Disease (NAFLD) are prevalent conditions.
Shared pathophysiological mechanisms involving bile acid (BA) signaling and homeostasis may link these diseases.

Purpose of the Study:

To explore the common pathways of altered bile acid signaling in IBS-D and NAFLD.
To investigate the role of fibroblast growth factor 19 (FGF19) in the pathogenesis of both conditions.
To identify potential therapeutic targets based on shared aberrant BA signaling.

Main Methods:

Review of existing literature on bile acid metabolism in IBS-D and NAFLD.
Analysis of the role of fibroblast growth factor 19 (FGF19) and its signaling pathways.
Examination of the relationship between hepatic BA production and serum FGF19 levels.

Main Results:

Altered ileal enterokine signaling and fibroblast growth factor 19 (FGF19) are implicated in IBS-D.
Reduced FGF19 levels are associated with increased hepatic bile acid production and diarrhea in some IBS-D patients.
Low circulating FGF19 levels are observed in subsets of patients with NAFLD, indicating altered enterohepatic BA homeostasis.

Conclusions:

Aberrant bile acid homeostatic signaling is a shared pathway in subsets of patients with IBS-D and NAFLD.
Understanding these shared pathways can guide the development of targeted therapies for both conditions.
Fibroblast growth factor 19 (FGF19) plays a crucial role in regulating bile acid and metabolic homeostasis.