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Could platelet distribution width predict coronary collateral development in stable coronary artery disease?
Isa Sincer1, Asli Kurtar Mansiroglu1, Emrah Erdal1
1Department of Cardiology, Abant Izzet Baysal University Faculty of Medicine Hospital, Bolu, Turkey.
Northern Clinics of Istanbul
|April 8, 2020
Summary
Platelet distribution width (PDW) and PDW to platelet ratio (PPR) may indicate coronary collateral development in stable coronary artery disease (CAD). Higher PDW levels are linked to inadequate collateral vessels, suggesting their potential as diagnostic markers.
Area of Science:
- Cardiology
- Hematology
- Vascular Biology
Background:
- Coronary collateral vessel (CCV) development is crucial in mitigating ischemia in chronic coronary artery disease (CAD).
- Hemogram parameters, particularly those related to platelets, have not been extensively studied in relation to CCV formation.
Purpose of the Study:
- To investigate the association between platelet distribution width (PDW) and PDW to platelet ratio (PPR) and the degree of coronary collateral development (CCD) in patients with stable CAD.
- To compare PDW and PPR levels in patients with adequate versus inadequate CCD.
Main Methods:
- A cohort of 398 patients with stable angina pectoris undergoing coronary angiography were analyzed.
- Patients were stratified into groups with inadequate (n=267) and adequate (n=131) CCD based on coronary angiography findings.
- Complete blood count parameters, including PDW and PPR, were measured prior to the procedure.
Main Results:
- Mean PDW was significantly higher in the inadequate CCD group (17.5%) compared to the adequate CCD group (12.4%) (p<0.001).
- Multivariate analysis identified PDW (OR: 1.432, p<0.001) and age as significant predictors of inadequate CCD.
- Receiver operating curve analysis indicated that a PDW >16.2% had 80% sensitivity and 66% specificity for predicting inadequate CCD.
Conclusions:
- PDW and PPR may serve as potential indicators of collateral vessel development in patients with chronic stable CAD.
- Elevated PDW levels are associated with poorer collateralization, suggesting a role in the pathophysiology of CAD progression.
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