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COVID-19 Outbreak: An Overview

Marco Ciotti1, Silvia Angeletti2, Marilena Minieri3,4

  • 1Virology Unit, Laboratory of Clinical Microbiology and Virology, Polyclinic Tor Vergata Foundation, Rome, Italy, marco.ciotti@ptvonline.it.

Chemotherapy
|April 8, 2020
PubMed

Insights

The novel coronavirus, SARS-CoV-2, emerged in Wuhan, China, and rapidly spread globally. Understanding its evolution, modeling its structure, and developing accurate diagnostics are crucial for control.

Area of Science:

  • Virology
  • Genomics
  • Epidemiology

Background:

  • An outbreak of unknown pneumonia in Wuhan, China, in late 2019 marked the emergence of a novel coronavirus.
  • This virus, provisionally named 2019-nCoV and now SARS-CoV-2, belongs to the Betacoronavirus genus.

Purpose of the Study:

  • To review current knowledge on the epidemiology, phylogenesis, homology modeling, and molecular diagnostics of SARS-CoV-2.
  • To highlight the importance of phylogenetic analysis, homology modeling, and diagnostic assays in managing the pandemic.

Main Methods:

  • Review of existing literature and data on SARS-CoV-2.
  • Analysis of genomic information and viral characteristics.

Main Results:

  • The SARS-CoV-2 genome was rapidly sequenced and made publicly available.
  • The virus has caused a global pandemic with significant health and economic impacts.

Conclusions:

  • Phylogenetic analysis is vital for understanding SARS-CoV-2 evolution.
  • Homology modeling aids in developing vaccines and therapies.
  • Sensitive and specific diagnostic assays are essential for controlling the spread of SARS-CoV-2.
Abstract

Keywords:
COVID-19PandemicPhylogenesisProtein modelingReal-time polymerase chain reactionSARS-CoV-2

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