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Updated: Dec 24, 2025

Isolation and Analysis of Traceable and Functionalized Extracellular Vesicles from the Plasma and Solid Tissues
Published on: October 17, 2022
Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers
Pasquale Simeone1,2, Giuseppina Bologna1,2, Paola Lanuti1,2
1Department of Medicine and Aging Sciences, University "G. d'Annunzio", Chieti-Pescara, 66100 Chieti, Italy.
Abstract:
Extracellular vesicles act as shuttle vectors or signal transducers that can deliver specific biological information and have progressively emerged as key regulators of organized communities of cells within multicellular organisms in health and disease. Here, we survey the evolutionary origin, general characteristics, and biological significance of extracellular vesicles as mediators of intercellular signaling, discuss the various subtypes of extracellular vesicles thus far described and the principal methodological approaches to their study, and review the role of extracellular vesicles in tumorigenesis, immunity, non-synaptic neural communication, vascular-neural communication through the blood-brain barrier, renal pathophysiology, and embryo-fetal/maternal communication through the placenta.
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