Related Experiment Video

Updated: Dec 24, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

9.9K

The Status of p53 Oligomeric and Aggregation States in Cancer

Guilherme A P de Oliveira1, Elaine C Petronilho1, Murilo M Pedrote1

  • 1Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Science and Technology for Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro, RJ 21941-901 Rio de Janeiro, Brazil.

Biomolecules
|April 9, 2020
PubMed

Insights

Mutant p53 proteins can become renegades, losing protective functions and driving cancer through altered structures and aggregation. Targeting these aberrant p53 forms offers new therapeutic strategies for cancer treatment.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Genetics

Background:

  • The tumor suppressor protein p53 is crucial for genome integrity.
  • Mutations can transform p53 into an oncogenic protein with altered functions.
  • Aberrant p53 oligomerization and aggregation are implicated in cancer progression.

Purpose of the Study:

  • To review the roles of different p53 oligomeric states in cancer.
  • To discuss research directions for targeting aberrant p53 functions.
  • To explore the link between p53 misfolding, aggregation, and cancer development.

Main Methods:

  • Literature review of studies on p53 oligomerization and cancer.
  • Analysis of p53 misfolding and prion-like aggregation in cancer biology.
  • Discussion of therapeutic strategies targeting mutant p53.

Main Results:

  • Mutant p53 exhibits altered DNA binding, novel interactions, and different oligomeric states.
  • p53 oligomerization status correlates with oncogenic activities in cancer progression.
  • Misfolded and aggregated p53 species play a significant role in tumorigenesis.

Conclusions:

  • Aberrant p53 oligomerization and aggregation are key drivers of cancer.
  • Targeting misfolded and aggregated mutant p53 represents a promising therapeutic avenue.
  • Further research into p53's structural transformations can lead to novel anti-cancer strategies.
Keywords:
gain-of-function effectsmutant p53oncogenesisp53 aggregationp53 oligomers

More Related Videos

Purification of Ubiquitinated p53 Proteins from Mammalian Cells10:55

Purification of Ubiquitinated p53 Proteins from Mammalian Cells

Published on: March 21, 2022

2.6K
Procedure and Key Optimization Strategies for an Automated Capillary Electrophoretic-based Immunoassay Method09:32

Procedure and Key Optimization Strategies for an Automated Capillary Electrophoretic-based Immunoassay Method

Published on: September 10, 2017

11.3K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
8.5K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.1K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.1K
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.9K
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
3.0K