[Properties of a collagen and monomycin complex]

The prolonged effect of a single application of a collagen-monomycin sponge was studied experimentally on albino rats on a model of a skin flat wound. The monomycin levels in the blood and tissues in the area of the sponge application for 14 days were determined by the biological method. The therapeutically effective concentration of monomycin, i.e. 3.8 gemma/ml was maintained in the general blood flow for 2 weeks. During this period the local antibiotic concentration was almost 5 times higher. The toxic effect of the collagen-monomycin complex was studied on rabbits and albino rats for 2 months with respect to the indices of the protein metabolism and the content of residual nitrogen and urea. The activity of cholinestrerase and the content of histamine in the blood were determined. No significant changes in the studied tests were observed during the period of the chronic experiment. The microstructure of the organs of the test animals did not differ from that of the intact animals. The collagen-monomycin complex had a prolonged antibacterial effect and was not toxic with respect to the the test animal.