Related Experiment Video

Updated: Dec 24, 2025

CO2-Lasertonsillotomy Under Local Anesthesia in Adults
05:07

CO2-Lasertonsillotomy Under Local Anesthesia in Adults

Published on: November 6, 2019

25.8K

Inflammatory Factors: Nonobese Pediatric Obstructive Sleep Apnea and Adenotonsillectomy

Yu-Shu Huang1, Wei-Chih Chin1, Christian Guilleminault2

  • 1Department of Child Psychiatry and Sleep Center, Chang Gung Memorial Hospital and College of Medicine, Taoyuan, Taiwan.

Journal of Clinical Medicine
|April 9, 2020
PubMed

Insights

Pediatric obstructive sleep apnea (OSA) involves inflammation. Adenotonsillectomy (T&A) improved OSA symptoms and inflammation markers, but persistent high IL-23 and HS-CRP indicate ongoing issues.

Area of Science:

  • Pediatric pulmonology
  • Sleep medicine
  • Immunology

Background:

  • Pediatric obstructive sleep apnea (OSA) is linked to inflammation.
  • Cytokines like IL-17 and IL-23 are implicated in OSA.
  • The study investigates inflammatory markers before and after adenotonsillectomy (T&A) in children with OSA.

Purpose of the Study:

  • To evaluate the impact of T&A on inflammatory markers in children with OSA.
  • To compare cytokine levels in children with OSA to controls.
  • To identify potential biomarkers for persistent sleep-disordered breathing after T&A.

Main Methods:

  • Prospective follow-up of 55 children (ages 4-12) with OSA undergoing T&A.
  • Polysomnography (PSG), blood tests (HS-CRP, TNF-α, IL-1, 6, 10, 12, 17, 23), and questionnaires administered pre- and post-T&A.
  • Comparison with 32 age-matched controls.

Main Results:

  • T&A significantly improved OSA symptoms, AHI, and oxygen saturation.
  • Children with OSA had higher baseline cytokine levels than controls.
  • Post-T&A, significant reductions were observed in HS-CRP, TNF-α, IL-1β, IL-10, and IL-17.
  • Persistent abnormal AHI correlated with unnormalized IL-23 and HS-CRP levels.

Conclusions:

  • Sleep-disordered breathing can persist post-T&A, maintaining a negative inflammatory effect.
  • High-sensitivity C-reactive protein (HS-CRP) and IL-23 may indicate persistent sleep-disordered breathing after T&A.
  • Monitoring these markers could aid in managing residual OSA.
Abstract

Keywords:
adenotonsillectomyinflammationinterleukinspediatric obstructive-sleep-apnea

More Related Videos

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue07:38

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue

Published on: June 14, 2020

7.9K
Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

20.4K

Related Concept Videos

Tonsillitis I: Introduction01:30

Tonsillitis I: Introduction

Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
1.4K
Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
349
Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
397
Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
9.7K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.1K
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
2.6K