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Bionanomaterials for bone tumor engineering and tumor destruction
Gary Blackburn1, Timothy G Scott, Ilker S Bayer
1Center for Nano Science and Technology, Department of Electrical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA. abiswas@nd.edu.
Journal of Materials Chemistry. B
|April 9, 2020
Summary
Multifunctional bionanomaterials show promise for targeted bone cancer treatment and drug delivery. Ongoing research focuses on developing advanced nanomaterial systems for improved therapeutic outcomes and cost-effective production.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Oncology
Background:
- Bone cancer treatment faces challenges requiring innovative therapeutic strategies.
- Multifunctional bionanomaterials offer potential for targeted drug and gene delivery to bone tumors.
- Advancements in materials science and engineering are crucial for developing novel cancer therapies.
Purpose of the Study:
- To provide a comprehensive review of recent advancements in bionanomaterials for bone cancer treatment.
- To examine various bionanomaterials and engineered bone scaffolds utilized in bone tissue engineering and cancer therapy.
- To discuss future perspectives in nanotechnology-enabled bone tumor treatment.
Main Methods:
- Review of literature on bionanomaterials (hydroxyapatite nanocrystals, nanometals, nanoscale conjugated copolymer, selenium, liposome) developed in the last six years.
- Analysis of the role of engineered bone scaffolds in cancer treatment and metastatic spread.
- Discussion of anticancer compounds like geminal bisphosphonates and their interaction with hydroxyapatite-based scaffolds.
Main Results:
- Bionanomaterials demonstrate potential for targeted bone tumor therapy and drug/gene delivery.
- Engineered bone scaffolds are emerging as targets for metastatic spread and tools for studying tumor dormancy.
- Geminal bisphosphonates exhibit strong affinity for hydroxyapatite scaffolds, enabling controlled release for anticancer activity.
Conclusions:
- Bionanomaterial-based approaches offer significant promise for advancing bone cancer treatment.
- Continued interdisciplinary research is essential for cost-effective, large-scale production of multifunctional nanomaterial systems.
- Nanotechnology holds substantial potential for future innovations in bone tumor therapy.
