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A pH-responsive controlled release system using layered double hydroxide (LDH)-capped mesoporous silica

Qishan Zheng1, Yanli Hao, Peirong Ye

  • 1Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, and Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China. lqguo@fzu.edu.cn.

Journal of Materials Chemistry. B
|April 9, 2020
PubMed
Summary

This study introduces a pH-responsive drug delivery system using layered double hydroxides (LDHs) and mesoporous silica nanoparticles (MSNs). The system releases loaded molecules in acidic conditions, enabling targeted delivery.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Drug Delivery

Background:

  • Controlled release systems are crucial for targeted therapeutic delivery.
  • Mesoporous silica nanoparticles (MSNs) offer high surface area for drug loading.
  • Layered double hydroxides (LDHs) possess tunable properties for various applications.

Purpose of the Study:

  • To develop a pH-responsive controlled release system using LDHs and MSNs.
  • To utilize the acid-decomposable nature of LDHs for triggered release.
  • To encapsulate guest molecules within MSNs and control their release via pH changes.

Main Methods:

  • Fabrication of MSNs.
  • Loading of guest molecules (Ru(bpy)3Cl2) in a neutral environment.
  • Coating of MSNs with LDH nanosheets via electrostatic adsorption.
  • Induction of guest molecule release in an acidic environment through LDH dissolution.

Main Results:

  • Successful encapsulation of guest molecules within the MSN-LDH system.
  • Demonstration of pH-responsive release, with significant release observed in acidic conditions.
  • Confirmation of LDH layer dissolution in acidic media, triggering guest molecule release.

Conclusions:

  • The developed MSN-LDH system functions as an effective pH-responsive controlled release platform.
  • LDHs serve as efficient inorganic nanovalves for triggered release applications.
  • This approach holds promise for targeted drug delivery systems sensitive to acidic environments.