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Updated: Dec 24, 2025
Surface Properties of Synthesized Nanoporous Carbon and Silica Matrices
Published on: March 27, 2019
Development of new drug delivery system based on ordered mesoporous carbons: characterisation and cytocompatibility
Christina Karavasili1, Elsa P Amanatiadou, Lambrini Sygellou
1Laboratory of Pharmaceutical Technology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece. dfatouro@pharm.auth.gr.
Abstract:
Ordered mesoporous carbons that encapsulate the poorly soluble compounds ibuprofen and indomethacin were systematically studied by means of X-ray diffraction (XRD), differential scanning calorimetry (DSC) and X-ray photon electron spectroscopy (XPS). The results showed marked differences in the release profiles of the two drug molecules in simulated gastric fluids. In vitro toxicity profiles appear to be compatible with potential therapeutic applications bringing them to the forefront as carriers of poorly water soluble drugs.
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