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Osteogenic potential of a biosilica-coated P(UDMA-co-MPS) copolymer
Matthias Wiens1, Thomas Niem, Tarek A Elkhooly
1Institute of Physiological Chemistry, University Medical Center, Johannes Gutenberg-University, Duesbergweg 6, D-55128 Mainz, Germany. wiens@uni-mainz.de.
Abstract:
A P(UDMA-co-MPS) copolymer was surface-functionalized through the polycondensation activity of the enzyme silicatein. The resulting biosilica coating significantly enhanced mineralization of osteoblastic cells, thereby revealing its osteogenic potential. Consequently, the functionalized copolymer may be explored as an alternative to conventionally used acrylics in applications where stable bone-material interfaces are required.
