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Updated: Dec 24, 2025
Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow
Published on: March 5, 2020
Blood compatibility of a new zwitterionic bare metal stent with hyperbranched polymer brushes
Xiaobo Wang1, Xiaoqiang Chen, Lei Xing
1Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China. maochun127@yahoo.cn jshen@njnu.edu.cn.
Abstract:
Different approaches have been used in developing new coronary stents to protect against thrombosis and minimize restenosis. Here we describe a new zwitterionic bare metal stent (BMS) surface based on 2-((bromobutyryl)oxy)ethyl acrylate (BBEA) hyperbranched polymer. The new BMS produced was studied for its blood compatibility. The hemocompatibility studied including platelet adhesion tests, hemolysis assay, morphological changes of red blood cells (RBCs), coagulation time tests, plasma recalcification time (PRT) assay, complement activation, and platelet activation at the molecular level. Moreover the cytotoxicity of BMS before and after modification was also characterized by MTT assays. Most assays had remarkable differences in the presence of the new zwitterionic BMS, indicating the importance of the zwitterion.
